IL33 and Crohn disease: Although one preliminary study (80) suggested a causative role for IL-33 in patients with inflammatory bowel disease (IBD), ST2s isoform mRNA in intestinal mucosa, is increased in patients with an active state of ulcerative colitis (UC) rather than Crohn’s disease (CD) and healthy controls, suggesting a potential role for IL-33/ST2 in wound or ulcer healing.