IRS1 and lung adenocarcinoma: In lung adenocarcinoma, ELANE infiltrates the tumor cells in the endothelium, leading to the down-regulation of insulin receptor substrate-1 (IRS-1), resulting in the enhancement of the interaction between phosphatidylinositol 3-kinase (PI3K) and the potent mitogen platelet-derived growth factor receptor (PDGFR), which eventually increase its proliferation ability (87).