Furthermore, tumor-infiltrating neutrophils use aconitate decarboxylase 1 (Acod1) to make itaconate, which regulates Nrf2-dependent ferroptosis and leads to the metastasis of breast cancer to the lungs by up-regulating the GM-CSF-JAK/STAT5-C/EBPb pathway (86). The gene discussed is ACOD1; the disease is neoplasm.