Ginsenoside Rb1 attenuated HF induced by MI/R injury by targeting the DUSP-1/TMBIM-6/VDAC1 pathway, regulating intestinal microbiota homeostasis and the equilibrium of the mitochondrial quality control network, as well as suppressing the NLRP3-mediated inflammatory response and pyroptosis (165). Here, DUSP1 is linked to hydrops fetalis.