TGFB1 and Myocardial fibrosis: Administration of angiotensin II (Ang II) induced myocardial fibrosis in mice, as indicated by the excessive deposition of collagen fibers, elevated expression levels of transforming growth factor-β (TGF-β) and connective tissue growth factor, along with NLRP3 inflammasome activation in cardiac tissues and heightened IL-1β secretion (85).