The restoration of CTRP3 expression ameliorated Ang II-induced myocardial fibrosis by inhibiting the P2X7R/NLRP3 inflammasome pathway to reduce α-SMA, collagen I/III, and matrix metallopeptidase (MMP) 2/9 expression (92). The gene discussed is NLRP3; the disease is Myocardial fibrosis.