Furthermore, studies have revealed that signaling pathways including adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) (65), silent information regulator of transcription (SIRT) 1/serine/threonine protein kinase B (Akt)/pyruvate dehydrogenase (PDH)/ROS (66), and E3 ubiquitin ligase membrane-associated RING finger protein 2 (MARCH2)/phosphoglycerate mutase 5 (PGAM5)/mitochondrial anti-viral-signaling protein (MAVS) (67) contribute to the exacerbation of cardiac inflammatory injury by activating the NLRP3 inflammasome, thereby exacerbating adverse cardiac outcomes caused by MI/R. Here, MARCHF2 is linked to myocardial infarction.