One noteworthy aspect is that the relationship between IFI30 and macrophages was also validated by several GBM single-cell datasets, for which we made the conjecture that IFI30 may be able to influence the survival status of M2 cells and thus exacerbate the malignant progression of GBM cells, as shown in subsequent cell communication analysis as well as laboratory work was confirmed. The gene discussed is IFI30; the disease is glioblastoma.