ITGB2 and cancer: Almost the vast majority of this positive correlation was dominated by the immune checkpoint stimulation pathway, the three ICI stimulation genes, ITGB2, CXCL10, and CCL5, were significantly positively correlated with IFI30 in almost all included cancer types, while the two ICI inhibitory genes, HAVCR2, and SLAMF7, exhibited significantly negative correlations with these cancer types, the future exploration of these five genes further exploration might account for novel orientations of ICI drug resistance or sensitization (Supplementary Figure S1D).