We then interfered with the expression level of IFI30 in the current co-culture system and demonstrated that although co-culture with M2 macrophages increased the viability of GBM cells, this malignancy was greatly reduced when the expression level of IFI30 was decreased, which more or less confirms that IFI30 is capable of interacting with M2 macrophages and thus influencing the growth of GBM cells (Figures 9I–L). Here, IFI30 is linked to glioblastoma.