To this end, basing on the existing consensus that TMB and MSI could significantly influence ICI therapy, we also investigated the correlation between the above and IFI30 in pan-cancer, showing a significantly positive correlation between TMB and IFI30 in 10 tumors, namely CESC, COAD, BRCA, STES, SARC, STAD, UCEC, THYM, READ, and a significant negative correlation in KICH, GBMLGG, TGCT, CHOL, and OV (Supplementary Figures S1E, F). The gene discussed is IFI30; the disease is cancer.