The nutritional support mechanism involves the recruitment of TAM-secreted bioactive molecules or activation of the ECs, leading to the generation of TAM-derived adrenomedullin (AMD), chemokine (C-X-C motif) ligand 12 (CXCL12), and other factors, which promote new blood vessel formation (73, 74). The gene discussed is CXCL12; the disease is age-related macular degeneration.