CD8A and neoplasm: further showed that V-9302 not only diminishes the uptake by malignant cells but also augments the infiltration of CD8+ T cells, elevates the count of Th1 cells secreting the anti-tumor effector molecule IFNγ within the TME, and mitigates tumor-induced glutamine deprivation in lymphocytes, ultimately attenuating the impairment of anti-tumor immunity (109).