Laboratory tests revealed evidence of an inflammatory state with marked hyper-eosinophilia [C-reactive protein (normal range: <5 mg/L): 134 mg/L, white blood cell count (normal range: 4.0–10.0 × 109/L): 20.3 × 109/L, eosinophils (normal range: 0.0–0.5 × 109/L): 12.18 × 109/L, 60% of leucocytes], myocardial injury [high-sensitivity troponin I (normal range: <20 ng/L): 15 182.4 ng/L], negative anti-neutrophil cytoplasmic antibodies (ANCAs), and an elevated brain natriuretic peptide level [BNP (normal range: <18.4 pg/mL): 315.8 pg/mL]. The gene discussed is NPPB; the disease is Increased total eosinophil count.