Unlike previously reported neural crest-specific Mll4 deletion models driven by Wnt1-Cre or Sox10-Cre, which exhibit cleft palate and neonatal lethality (Shpargel et al., 2020), our Mll4-cKO mice did not show cleft palate or neonatal lethality. The gene discussed is SOX10; the disease is cleft palate.