Surprisingly, compared to the previously reported neural crest-specific Mll4 deletion (Mll4fl/fl;Wnt1-Cre and Mll4fl/fl;Sox10-Cre) mice, which exhibited cleft palate and neonatal lethality (Shpargel et al., 2020), our palatogenesis-specific Mll4-cKO mice did not show cleft palate or lethality at birth and could grow up into adult mice that did not show much noticeable changes when grossly examined for exterior appearance at 10 weeks (Figures 1C, G). The gene discussed is KMT2D; the disease is cleft palate.