TTN and heart failure: Zhang et al. reported that the lactylation of α-MHC at K1897 affected the global lactylation of α-MHC, which promoted a significant increase in the interaction between α-MHC and Titin and reduced the possibility of heart failure (Zhang et al., 2023a), and p300 and SIRT1 acted as lactyltransferase and delactylase enzymes of α-MHC, respectively.