SLC13A1 and lumbar disk degenerative disorder: ,37,38 A genome-wide association study of intervertebral disc disorder performed by Bjornsdottir et al38 in 2022 found SLC13A1 nonsense variants p.(Arg12∗) and p.(Trp48∗) conferred the largest risk effect (LOF burden OR = 1.44, P = 3.1 × 10−11).