However, a meta-analysis of subgroups between Asian and non-Asian participants to characterize this association revealed that FTO polymorphism is significantly associated with an increased risk of T2D in Asian subjects with respect to all genetic models, e.g., dominant, recessive, and AC vs CC, except for the US subgroups, in which differences between the AA and AC models were significant. This evidence concerns the gene FTO and type 2 diabetes mellitus.