KC was traditionally considered a non-inflammatory disease until Zhou et al. and Pouliquen et al. published articles in 1996, uncovering elevated levels of vimentin, tenascin Transforming growth factor beta (TGF-β), Interleukin-1 (IL-1), and Prostaglandin E2 [36,37]. Here, TGFB1 is linked to keratoconus.