MBNL1 and myotonic dystrophy type 1: The overactivation of autophagy has been observed in MuSCs differentiated from induced pluripotent stem cells (iPSCs) derived from patients with myotonic dystrophy type 1 (DM1) (Box 1), in which muscleblind-like 1 (MBNL1) expression is reduced (Song et al., 2020).