2018; Swanson et al. 2018). While previous studies have linked NPTX2 upregulation to neuroprotection in ischemic stroke, some suggest it may also be linked to neuronal damage (Schwarz et al. 2002; Cai et al. 2019; Thatipamula and Hossain 2014; Lu et al. 2003). This evidence concerns the gene NPTX2 and ischemic stroke.