2022; Mohamed Fuad et al. 2020; He et al. 2018; Huang et al. 2022). Serum NPTX2, a novel biomarker of synaptic dysfunction associated with cognitive function in neurodegenerative diseases (Galasko et al. 2019; Shao et al. 2020; van der Ende et al. 2020; Xiao et al. 2017; Swanson and Willette 2016; Nilsson et al. 2023), was positively correlated with total MoCA scores and cognitive subdomains. The gene discussed is NPTX2; the disease is neurodegenerative disease.