This process is activated by the adenosine A2B receptor (ADORA2B)‐S1P signaling cascade to mitigate hypoxia including high altitude (D'Alessandro and Xia 2020; Sun et al. 2016; Liu et al. 2016; Qiang et al. 2021; Zachara 1975), hemolytic disease (Sun et al. 2015), and chronic kidney disease (Peng et al. 2019; Xie et al. 2020). The gene discussed is ADORA2B; the disease is chronic kidney disease.