This event triggers the transcription of downstream molecules such as IFNs and ISGs, which elicits robust antiviral effects.21,22 Furthermore, research has highlighted the preventive function of IRF3 in viral inflammation, colorectal tumor progression, and the regulation of cell death, inflammatory reactions, and fibrosis.23–25 Nonetheless, the specific association between IRF3 and gastric cancer, particularly concerning H. pylori infection, remains inadequately elucidated. The gene discussed is IRF3; the disease is colorectal neoplasm.