This suggests a promising avenue for further comprehensive exploration in our forthcoming research endeavors.53 The INS-GAS mice are a transgenic mouse model, characterized with gastric somatostatin overexpression, has emerged as a valuable tool for studying gastric cancer development in response to H. pylori infection.54–58 Following 4 months of H. pylori infection, INS-GAS mice exhibited notable inflammation infiltration and partial glandular metaplasia in the stomach, concomitant with the extensive activation of ACVR1, particularly pronounced at the site of H. pylori colonization. The gene discussed is ACVR1; the disease is gastric cancer.