The CLA concentration in the feces of colon significantly negatively correlated with the number of colon tumors, tumor volume, and high-grade lesions in the colon (Figures 2l–n), which indicated that the abilityof Bifidobacterium to produce CLA in the feces of colon may be related to its effectiveness in relieving CRC. The gene discussed is SELPLG; the disease is colonic neoplasm.