In addition, CLA can regulate CRC cells by inhibiting the NF-κB pathway, and activating PPAR-γ can inhibit the NF-κB signaling pathway,56 inhibiting the proliferation of CRC cells.57 Therefore, CCFM683 can prevent CRC by regulating the NF-κB signaling pathway and cytokines via the CLA-PPAR-γ axis. This evidence concerns the gene SELPLG and colorectal carcinoma.