In addition, inflammation, bleeding, and other symptoms caused by CRC are related to the activation of the NF-κB signaling pathway, and PPAR-γ is an important target for regulating this pathway.54 Therefore, we analyzed the effect of CCFM683 and PPAR-γ inhibitors on the NF-κBsignaling pathway. This evidence concerns the gene NFKB1 and colorectal carcinoma.