In our previous work, biomarkers of inflammation were identified in preclinical IBD‐models, including Intercellular adhesion molecule 1 (ICAM1) and Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1).[44] Here, the aim was to conjugate the constant region of anti‐ICAM1 antibodies onto SPIONs via CuAAC reaction to control the antibody orientation and ensure ligand exposure of its binding region. Here, ICAM1 is linked to inflammatory bowel disease.