PRKDC and neoplasm: Additionally, a rise in Beclin‐1 expression and shift from LC3‐I to LC3‐II induced by anlotinib was notably examined through IHC staining and western blotting assays in tumours transfected with the METTL3 lentivirus; however, this effect was abolished by co‐transfection with the PRKDC shRNA lentivirus (Figure 7F and G).