Numerous studies have demonstrated that the margin area, recognised as the most active part of liver cancer, is enriched with immune cells such as CCR1+ CD14+ monocytes, CD20+ B cells, CD4/CD8 double‐positive T cells, etc.48, 58In addition, the condition of the margin area influences tumour progression and recurrence in patients with liver cancer. This evidence concerns the gene CD8A and neoplasm.