scRNA‐seq technology has revealed distinct functional subtypes of T cells in HCC, including exhausted CD8+ T cells and Tregs preferentially enriched and clonally expanded in tumour tissues and innate‐like CD8+ T cells, namely, CD161+ CD8+ T cells, with low cytotoxicity and clonal expansion, leading to compromised antitumour immunity and early relapse.6, 60, 61. Here, CD8A is linked to neoplasm.