Core drivers (TP53, TERT and WNT signalling) and combinations of infrequent alterations in various cancer pathways cloud be captured in HCC and core driver genes (TP53, ARID1A, KRAS, SMAD4 and BAP1) with characteristic molecular alterations including fusion transcripts involving fibroblast growth factor receptor 2 (IGFR2) and the protein kinase A pathway, and IDH1/2 mutation could be found in ICC by multi‐omics tools such as whole exome sequencing.118. The gene discussed is TP53; the disease is intrahepatic cholangiocarcinoma.