Interestingly, central carbon metabolism in cancer (HK2, MAPK3, MYC, PFKP, PKM2, SLC16A3), galactose metabolism (B4GALT2, HK2, PFKP) and fructose and mannose metabolism (HK2, PFKFB4, PFKP) are associated with metabolism. This evidence concerns the gene PKM and cancer.