MMP2 and neoplasm: Using GAL4/LexA binary system, we knocked down expression of ERK or Mmp2 in APCs of yki3SA-tumor-bearing flies and consistently found that host wasting, including bloating, lipid loss, and hyperglycemia, were robustly improved without affecting yki3SA tumors in the gut at day 6 (Fig. 3d‒g).