Strikingly, as compared to marginal effects of APC Pvr inactivation in non-tumor adult flies, we observed that Pvr inactivation in APCs of yki3SA-tumor-bearing flies resulted in a significant decrease in Akh response (Akh and tobi expression) and robustly improved host wasting, including bloating, lipid loss, hyperglycemia, muscle dysfunction, and ovary atrophy without affecting tumor growth at day 6 (Fig. 2g‒k and Supplementary Fig. S5a, b). The gene discussed is PVR; the disease is neoplasm.