GCG and Glucose intolerance: We analyzed the carbo-lipid metabolism in cachectic ApcMin/+ mice after 18 weeks and observed upregulation of glucagon-target genes in the liver, glucose intolerance, higher blood glucose levels, as well as hepatic glycogen depletion (Fig. 6f‒h and Supplementary Fig. S9a, b), as compared to age-matched wild-type C57BL/6 mice.