This finding suggests a novel impact of AXL inhibition on adoptive T-cell therapy’s immunological modulation.159 Furthermore, AXL-ADC and anti-AXL-CAR-T cells additionally showed potent and targeted cytotoxicity, improved primary tumor TME, and reduced lung metastasis in breast and lung cancer models, rendering it a plausible cancer prevention strategy.160 Consequently, extensive clinical research is ongoing to modify the CAR construct and explore various immune cell types as platforms to enhance the safety and effectiveness of CAR-based treatments. The gene discussed is AXL; the disease is lung cancer.