This emphasizes the significant role of AXL in invasion and migration processes.76 Furthermore, AXL regulates genes associated with metastasis (e.g., somatostatin receptor 2 (SSTR2), fms-related receptor tyrosine kinase 4 (FLT4), matrix metalloproteinase 10 (MMP10), kisspeptin-1 (KISS1), collagen type IV alpha 2 chain (COL4A2), RAR-related orphan receptor B (RORB)) and is linked to the expression of stem cell markers.77 It also facilitates the migration and invasion of breast cancer stem cells. This evidence concerns the gene RORB and breast carcinoma.