AKT1 and cancer: Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in various cancers, where PDGF/PDGFR signaling activation influences cell proliferation, migration, invasion, and angiogenesis through the PI3K-PKB/Akt and MAPK/ERK pathways.238 AXL and PDGFR demonstrate crosstalk, as observed in gastrointestinal stromal tumors (GISTs) treated with imatinib mesylate.