AXL and cutaneous squamous cell carcinoma: In cutaneous squamous cell carcinoma (SCC), AXL contributes to cell invasiveness and stemness by modulating Wnt and TGF-β signaling pathways and disrupting cell-to-cell adhesion.103 Furthermore, suppressing AXL through inhibitors or shRNA extends the survival of chronic myeloid leukemia (CML) mice and reduces the growth of leukemia stem cells (LSCs).