AXL and leukemia: The potential of FLT3-ITD inhibitors to induce apoptosis is influenced by the GSK-3β/Mcl-1 axis, which is regulated by both FLT3-ITD and AXL signaling pathways.237 Overall, combined inhibition of FLT3 and AXL presents a promising therapeutic strategy for leukemia, offering new alternatives to overcome resistance and improve patient outcomes.