AXL and lung cancer: For instance, in ovarian cancer, AXL signaling is modulated by the EMT state, with mesenchymal subtypes augmenting GAS6/AXL signaling.184 Similarly, TGF-β/SMAD4 activation facilitates YAP-dependent AXL expression, contributing to acquired chemoresistance in mesenchymal lung cancer cells.185 Further investigations into these molecular mechanisms could reveal additional targetable pathways for AXL-EMT regulation.