For instance, the human papillomavirus type 16E6 (HPV16E6) oncoprotein has been shown to upregulate AXL expression in cervical cancer via the MAGI-2/PTEN/Akt/MZF1 network, increasing tumor invasiveness and promoting immune evasion by reducing responsiveness to NK cells-mediated lysis.126. This evidence concerns the gene AKT1 and neoplasm.