In addition, Li et al. identified that the clustering of c-MET, AXL, ELMO2, and DOCK180 proteins on the plasma membrane constitutes a crucial mechanism through which HGF-dependent signaling initiates RAC1-mediated migration and invasion of glioblastoma cells.219 Notably, in the HGF/c-MET pathway, AXL (in its higher-molecular-weight form, p140) undergoes transphosphorylation at Tyr-779, potentially playing a significant role in tumorigenesis. This evidence concerns the gene HGF and glioblastoma.