CD19 and neoplasm: Interestingly, GAS6-CAR-T cells have demonstrated effective targeting of TAM-positive pancreatic tumor cells and suppression of in vivo xenograft tumor growth with minimal toxicity by targeting both tumor cells and tumor-associated macrophages.158 In a recent study, Sakemura et al. found that inhibiting AXL with TP-0903 can modulate the function of CART19, enhancing its anticancer effect towards CD19+ cells through the suppression of Th2 cells and M2 macrophages.