AXL and neoplasm: However, co-targeting both MERTK and AXL significantly inhibited tumor growth by affecting several signaling pathways, including Akt, STAT6, P70S6K, S6RP, and C-RAF.215 Interestingly, the dual inhibitor INCB081776 demonstrated immunomodulatory and antitumor effects primarily by inhibiting MERTK activation in macrophages.