Global deletion of FGFR4 (FGFR4−/−) protects mice from LVH caused by chronic high-phosphate diet.27 To test if FGFR4 deletion also protects against LVH in CKD, we subjected FGFR4−/− mice to 16 weeks of adenine diet. The gene discussed is FGFR4; the disease is chronic kidney disease.