COL12A1 and Ehlers-Danlos syndrome: Therefore, striking more widely distributed joint laxity, less prominent contractures, and nonprogressive muscle weakness allowing for some clinical improvement of motor function (in particular in patients with less severe involvement at the outset), are important features to help distinguish patients with COL12A1 myopathic EDS from those with COL6‐RD in whom the muscle involvement can be quite progressive and dystrophic in nature, including progressive respiratory failure.