IL6 and chronic kidney disease: Interleukin-6 accelerates the progression of CKD by aggravating kidney injury and initiating its complications, especially the chronic vascular disease (CVD) [59]. Moreover, melatonin may reduce inflammation through downregulation nuclear factor kappa B [60], which suppresses pro-inflammatory markers like hs-CRP [55] Additionally, melatonin may decrease inflammatory markers by scavenging toxic oxygen derivatives in inflamed tissues [61].