The levels of both TNF-α and TWEAK were increased more than two times in the blood of TB mice compared to controls (TNF-α: 13.05 ± 2.29 pg/mL versus 5.97 ± 1.20 pg/ mL, P < 0.05; TWEAK: 5.8 ± 4.14 pg/mL versus 2.02 ± 0.60 pg/ mL, P = 0.067) (Fig. 7C). The gene discussed is TNFSF12; the disease is tuberculosis.