Furthermore, a direct role for TNF-R2 stimulation in VS tumor growth is also plausible, as TNF-R2 has been shown to promote tumor cell proliferation through the phosphoinositide 3-kinase/AKT signaling pathway [56], a pathway known to be inhibited by the merlin protein in healthy Schwann cells [57]. Here, TNFRSF1B is linked to neoplasm.