These included FBXW7, POT1, TP53, SETD2, DDX3X, TBL1XR1, KDM6A, MYC, RARA, SUZ12, PPP6C, PTPRC, CIC, and SMARCA4, of which TBL1XR1 and MYC in particular are listed as implicated in various types of human B-cell lymphoma (Fig. 2). The gene discussed is POT1; the disease is B-cell non-Hodgkin lymphoma.