EZH2 and plasma cell myeloma: Indeed, it has been recently demonstrated that PVT1 acts as a molecular partner of PRC2 in multiple myeloma through its physical interaction with the enzymatic subunit EZH2, that catalyzes H3K27 trimethylation [38], and it was previously shown that PVT1 is involved in non-small cell lung cancer metastasis through EZH2 [51].