Comparing the dataset generated here with previously published data identifying functional lncRNAs in multiple cancer models [17], FGD5-AS1, EPB41L4A-AS1 and PVT1 were selected for further experimental evaluations based on their fitness score demonstrated in BC cell models, average expression and ERα-enrichment in our experimental models (Fig. 1D, E). The gene discussed is PVT1; the disease is breast cancer.