In particular, the experimental results identified PVT1 as a core molecule in the composition of a transcriptional repressive complex allowing the functional cooperation of PRC2 and ERα through PVT1-mediated association of EZH2 and the receptor with the transcription unit of tumor suppressive genes such as BTG2 (BTG family member 2/NGF-inducible anti-proliferative protein PC3). The gene discussed is EZH2; the disease is neoplasm.