To quantify how well our 100 kb model performed compared with FACS, we calculated the discordance percentage between our in silico predictions and the FACS metadata of three cell types: wild-type (WT) HCT-116 colon cancer cells (n = 713), HCT-116 double knockout (DKO1) cells in which both the maintenance DNA methyltransferase DNMT1 and the de novo DNA methyltransferase DNMT3B were knocked out (n = 668), and GM12878 B cells (n = 3180). Here, DNMT1 is linked to colonic neoplasm.