Inhibitors such as 2,3,7,8-tetrahydroxy-benzopyranol[5,4,3-cde]benzopyran-5,10-dione (TBBD) and ellagic acid have shown promise in attenuating retinal pigment epithelium cell apoptosis during diabetic retinopathy progression by blocking CARM1 activity and H3R17 dimethylation (32). Here, CARM1 is linked to diabetic retinopathy.