Of note, most of these multi-omic drivers were hidden drivers of COVID-19 severity (ACTN4, ATP6AP2, CD4, DUSP3, GRAP2, HMOX1, IKBKG, IL10RA, IL17RA, IL6, JUN, LAMP2, LYN, NFATC1, S100A11, and SNAP23) (Supplementary Fig. S11). Here, ACTN4 is linked to COVID-19.