To showcase APNet’s capacity to expose non-obvious connections among clinically predictive drivers and pathways, we investigated how ACAA1 (acetyl-Coenzyme A acyltransferase 1), a key regulator of fatty acid β-oxidation in peroxisomes and a highly predictive COVID-19 severity driver (based on APNet from the bulk proteomic scenario), is connected to other equally predictive proteomic drivers. The gene discussed is ACAA1; the disease is COVID-19.