More precisely, extracted signatures showed that the presence of Arginase-1 and Filaggrin is characteristic of healthy subjects and a complementary differential analysis revealed that these proteins were indeed significantly underexpressed for AD samples (adjusted P-values of 5.32×10−7 and 6.96×10−4, respectively, with moderated t-tests from limma; see Supplementary Table S1 and Supplementary Section S5.4 of Supplementary Material). This evidence concerns the gene ARG1 and Alzheimer disease.