Indeed, small proline-rich proteins (as SPRR1B, SPRR2E), implied in keratinization process, and fatty acid binding proteins (as FABP5), implied in fatty acid metabolism, were found to be highly expressed in nonlesional/lesional skin of AD and psoriatic patients (Nakajima et al. 2024, Rusinol and Puig 2024). This evidence concerns the gene SPRR2E and Alzheimer disease.