Among them, 3 genes (NUDT13, PYROXD2, and YPEL3) were validated through RT‐qPCR using a cohort comprising 36 paired early‐stage CRC samples and 14 paired adenomas, as well as through datasets from UCSC Xena (Figure 1B; Figure S2A–C, Supporting Information). The gene discussed is YPEL3; the disease is adenoma.