In conclusion, we identified NUDT13 as a roadblock in the progression from colorectal adenoma to CRC, and revealed that NUDT13 stabilizes PKM1 protein by reducing the PARylation that is catalyzed by PARP1, thereby reprogramming the metabolic propensity of CRC cells (Figure 7N). The gene discussed is PARP1; the disease is colorectal carcinoma.