As PKM2 has been shown to strongly promote tumor progression in various cancers,[23, 24, 25] we sought to investigate whether the downregulation of PKM2 contributes to the phenotype of NUDT13 and observed that NUDT13 had no significant effect on the expression of key downstream targets of PKM2 (Figure S6M, Supporting Information). The gene discussed is PKM; the disease is neoplasm.