Mechanistically, NUDT13 directly binds and stabilizes PKM1 protein by reducing its poly ADP‐ribosylation (PARylation), which is catalyzed by PARP1 at E275/D281/E282/E285/D296, thereby inducing an oxidative phosphorylation (OXPHOS) phenotype in CRC cells. This evidence concerns the gene NUDT13 and colorectal carcinoma.