PKM catalyzes the last committed step of glycolysis, converting phosphoenolpyruvate to pyruvate.[41] Two PKM isoforms, which are splice variants with different activities, influence the pathway of glucose metabolism in tumor cells.[15, 17, 18, 42] PKM1 promotes glucose oxidation, while PKM2 generally signals for fermentation.[15, 16, 17, 18, 24, 43] Given that aerobic glycolysis is known for its ability to provide conditions catering to the needs of proliferative tumor cells, PKM1 may inhibit tumorigenesis by disrupting glycolysis. This evidence concerns the gene PKM and neoplasm.