Also, tumor cells will transform into artificial antigen-presenting cells when infected by herpes simplex virus type 1 (HSV-1) based OVs encoding OX40 ligand and IL-12, then the effectiveness of TIL therapy will be reinforced under the combination of OV-OX40L/IL12 and TILs therapy, achieving complete tumor regression, triggering antitumor immune memory, and reprogramming immune cells in TME [264]. This evidence concerns the gene TNFSF4 and neoplasm.