IFNG and neoplasm: In terms of the adaptive immunity, Sethi V et al. proposed that the gut microbiome modulates tumor growth, once depleted, it contributes to an increase in interferon-gamma (IFN-γ) with a corresponding decrease in IL-10/17 derived from CD8 + T cells, suggesting that the gut microbiome community requires adaptive immunity to exert its immunomodulatory effects [130].