AIF1 and Alzheimer disease: The group of 3xTg-AD + A mice administered with alcohol exhibited a higher number of GFAP-positive cells (ie, activated astrocytes) and Iba1-positive cells (ie, activated microglia) in the hippocampal CA1 region than 3xTg-AD + W mice; the increase in GFAP-positive cells was reversed by rolipram treatment.