The colocalization results support the causal association between GCKR and GDM by strong evidence of colocalization (PPH4 = 0.997), indicating that GCKR and GDM were linked through the shared variant in the 200 kb locus around the GCKR, and the cis‐pQTL rs1260326 is likely to alter circulating GCKR levels to affect GDM (SNP. The gene discussed is GCKR; the disease is gestational diabetes.