disclosed that SPP could promote lung cancer and breast cancer progression by facilitating the degradation of FKBP8 to enhance mTOR signaling.[21] To confirm whether circSATB1 could regulate the metastasis of CRC cells via activating mTOR signaling through the proteasomal degradation of FKBP8, WB was performed to detect the activity of mTOR signals. The gene discussed is HM13; the disease is breast carcinoma.