RNF25 is an E3 ubiquitin‐protein ligase with a RING finger motif involved in the ubiquitination of eEF1A and a discrete set of ribosomal proteins.[61] RNF25 is known to promote liver cancer metastasis by mediating the degradation of E‐cadherin protein under oxidative stress conditions.[62] In CRC, RNF25 has been shown to cooperate with CARM1 to suppress ferroptosis by binding to ACSL4 and promoting its ubiquitylation and degradation.[63] However, the specific role of RNF25 in CRLM has not been previously investigated. The gene discussed is ACSL4; the disease is colorectal carcinoma.