In contrast, the application of sh1‐Circ in DLD‐1 cells led to a significant prolongation of the half‐life of FKBP8 (Figure5A,B).Ubiquitin–proteasome system(UPS) and autophagy‐lysosome system are two important systems to adjust protein degradation in the post‐transcriptional manner.[17, 18] Thus, we treated CRC cells with proteasome inhibitor MG‐132, the lysosome inhibitor chloroquine, or the autophagy inhibitor 3‐Methyladenine (3‐MA) to determine which was the pivotal system. Here, FKBP8 is linked to colorectal carcinoma.