In this study, RNA pulldown, IB and RIP assays confirmed that RNF25 could specifically bind to circSATB1 (Figure6A–C).IF staining and FISH assays showed that circSATB1, RNF25, and FKBP8 mainly co‐localized in the cytoplasm of CRC cells (Figure 6D). The gene discussed is RNF25; the disease is colorectal carcinoma.