Studies on mice have uncovered that genetic deletion of Nppa or its target receptor natriuretic peptide receptor A enhances cardiac hypertrophy and LV dilatation and deteriorates LV systolic function after TAC‐induced pressure overload,37, 38 while deletion of Nppb does not affect susceptibility for pathological cardiac hypertrophy.39 This evidence concerns the gene NPPB and cardiac hypertrophy.