Disorganized actin fibers promote YAP1/TAZ nuclear enrichment independent of the core Hippo kinases,[22] and, in meningioma cells, the knockdown of NF2 RNA increases YAP1 expression and nuclear localization via the Hippo pathway.[23] We similarly observed that YAP1 and TAZ were mainly located in the nuclei of NF2−/− 1 and NF2−/− 2, but not WT, hiPSCs (Figure 3A). This evidence concerns the gene WWTR1 and meningioma.