BMP4 and neoplasm: Activated myofibroblasts are the primary producers and organizers of extracellular matrix proteins during wound healing (i.e., fibrogenesis),[30] and disruption of their tightly controlled role can result in pathological scarring of organs or tumor stroma remodeling.[31] TGFβ[32] and BMP[33] ligands or their downstream effectors are involved in fibrosis, and TGFB2 and BMP4 mRNA were highly expressed in NF2−/− 1 cells (Table S2B, Supplementary Table).