LIMA1 and neoplasm: LIMA1, a crucial regulator of the actin cytoskeleton, is initially identified as a frequently downregulated tumor suppressor in epithelial tumors.[15] LIMA1 deficiency can disrupt cytoskeletal dynamics, affect cell motility, and impair intercellular adhesion, ultimately promoting tumor growth, invasion, and migration.[28] Additionally, LIMA1 plays a vital role in regulating intestinal cholesterol absorption.[17] However, its involvement in hepatocyte lipid metabolism and MASLD progression remains unclear.