Additionally, compared with their AAV8‐TBG‐LIMA1‐WT counterparts, AAV8‐TBG‐LIMA1ΔT662 injection exhibited decreases in systemic insulin resistance, steatosis severity, inflammation and fibrosis in HFD‐fed and CDAHFD‐fed LIMA1 HKO (hepatocyte‐specific knockout) mice. Here, SERPINA7 is linked to Insulin resistance.