Mechanistic studies revealed that steatosis upregulated Host cell factor 1 (HCF1) and O‐GlcNAc transferase (OGT) expression, leading to catalyzed O‐GlcNAcylation at the T662 site of LIMA1 and subsequent inhibition of its ubiquitin‐dependent degradation. The gene discussed is HCFC1; the disease is steatosis.