After HFD and CDAHFD diet feeding, the LIMA1 HKO/LIMA1ΔT662 mice exhibited systematic amelioration of MASLD‐related phenotypes, as indicated by the changes in insulin resistance (as shown by IPGTT and ITT), fast glycemia and TG contents, and serum ALT and AST levels (Figure 8E,F,L). The gene discussed is LIMA1; the disease is metabolic dysfunction-associated steatotic liver disease.