RIPK3 and neoplasm: The induction of necroptosis for “cold‐to‐hot tumor transition” has been limited due to the epigenetic suppression of RIPK3 expression in cancer cell lines and primary cancers.[13a,b] Attempts to deliver or restore RIPK3 through various approaches have been largely unsatisfactory owing to the difficulty in controlling RIPK3 activity with precise spatial and temporal resolution.