The induction of necroptosis for “cold‐to‐hot tumor transition” has been limited due to the epigenetic suppression of RIPK3 expression in cancer cell lines and primary cancers.[13a,b] Attempts to deliver or restore RIPK3 through various approaches have been largely unsatisfactory owing to the difficulty in controlling RIPK3 activity with precise spatial and temporal resolution. This evidence concerns the gene RIPK3 and cancer.