Recent interest in necroptosis has largely stemmed from its potential to increase tumor immunogenicity and stimulate antitumor immunity, making it a promising strategy for cancer immunotherapy.[32] While traditional methods that utilize chemicals like TSZ effectively induce necroptosis through the sequential activation of RIPK1, RIPK3, and MLKL, these approaches lack spatial confinement and precise temporal control. This evidence concerns the gene RIPK3 and cancer.