RIPK3 and neoplasm: Recent interest in necroptosis has largely stemmed from its potential to increase tumor immunogenicity and stimulate antitumor immunity, making it a promising strategy for cancer immunotherapy.[32] While traditional methods that utilize chemicals like TSZ effectively induce necroptosis through the sequential activation of RIPK1, RIPK3, and MLKL, these approaches lack spatial confinement and precise temporal control.