A previous study found that HUWE1 is an ubiquitin E3 ligase of MUTYH that mediates the ubiquitination and degradation of MUTYH in tumor cells.[22] Our results showed that protein levels of the E3 ligase HUWE1 were upregulated in the kidneys of cisplatin‐ or FA‐treated mice, and overexpression of HUWE1 aggravated cisplatin‐induced tubular cell death. Here, MUTYH is linked to neoplasm.