Additionally, a study reported a significant reduction of ACOD1 expression in alveolar macrophages during pulmonary fibrosis, where it plays a crucial role in disease progression.[59] Since obesity has been shown to promote the development of pulmonary fibrosis,[60] these observations indirectly support our finding of ACOD1 downregulation in alveolar macrophages under obesity. The gene discussed is ACOD1; the disease is obesity due to melanocortin 4 receptor deficiency.