First, we specifically overexpressed ACOD1 in the lungs of HFD mice, fed a high‐fat diet for 16 weeks, via airway administration of adeno‐associated virus (AAV‐ACOD1, 5 × 1012 vg ml−1; 100 μL mouse−1, 5 × 1011 vg mouse−1) to counteract the obesity‐induced reduction in ACOD1 levels (Figure 2I), with a particular focus on its effects within the lungs. This evidence concerns the gene ACOD1 and obesity due to melanocortin 4 receptor deficiency.