Nrf2 has been widely recognized as a downstream target of ACOD1, playing a crucial role in mediating anti‐inflammatory and antioxidant responses.[30, 41, 51, 52, 53, 54] To elucidate the downstream mechanisms of ACOD1 in the context of aggravated lung injury in obesity, we assessed Nrf2 expression levels in both NCD and HFD mice. This evidence concerns the gene ACOD1 and obesity due to melanocortin 4 receptor deficiency.