GFI1 and obesity due to melanocortin 4 receptor deficiency: Based on existing literature, GFI1 can undergo SUMO[76] and ubiquitin[77] modifications, and obesity has been linked to enhanced SUMOylation.[78] These findings imply the potential immune and metabolic changes in obesity that may alter GFI1 protein levels through post‐translational modifications, providing new directions for future research and enhancing our understanding of the mechanisms underlying lung injury exacerbated by obesity.