MMP7 and CCDN1, downstream effectors of LEF1, are crucial factors involved in tumor metastasis and cell cycle progression.[42, 43, 44] RNA sequencing and qRT‐PCR demonstrated that HCETSR inhibition of LEF1 led to suppression of MMP7 and CCDN1 transcription (Figure 6K–M). The gene discussed is LEF1; the disease is neoplasm.