For instance, AS‐tDR‐007333 binds to HSPB1 to promote NSCLC malignancy,[52] and 5′‐tRFCys promotes metastatic and metabolic effects in breast cancer by binding Mthfd1l and Pafah1b1 transcripts.[53] In this study, RNA sequencing and LC‐MS/MS analysis indicated that HCETSR controls focal adhesion, ECM‐receptor interaction, and cytoskeleton regulation. This evidence concerns the gene MTHFD1L and breast cancer.