The EDN3+ meningeal fibroblasts, as the subcluster for outgoing signals, show enriched signaling pathways such as CCL, ncWNT, L1CAM, and CXCL (Figure S3C, Supporting Information), which are associated with inflammation and angiogenesis.[27, 34, 35] Notably, in the ncWNT (non‐canonical WNT) signaling pathway, an emerging player in cerebrovascular diseases, we observed increased ligand WNT5A in EDN3+ meningeal fibroblasts and its receptor FZD3 in a subcluster of SWS capillary endothelium (Figure 4I). Here, EDN3 is linked to cerebrovascular disorder.