Indeed, upon meticulous examination of the differentially expressed genes (DEGs), we found that AAMs overexpressed SPP1 and CXCL8 (Figure 2D), which have been widely reported to facilitate tumor progression and metastasis.[25] Subsequently, we implemented a GSVA analysis, which led to the identification of significant enrichment of hypoxia and angiogenesis pathways within AAMs (Figure 2E). Here, SPP1 is linked to neoplasm.