SPP1 functions as a proverbial secretory protein that exerts pro‐tumor functions.[25a] To investigate the role of SPP1 in OC progression and metastasis, we showed that SPP1 knockdown reduced vascular permeability and impeded the migration, invasion, and proliferation of ovarian cancer cells (Figure S7A–F, Supporting Information). This evidence concerns the gene SPP1 and neoplasm.