CHI3L1 and glioblastoma: Moreover, the high MSN group was significantly enriched in the VERHAAK_MES_2017 pathway, whereas the low MSN group was enriched in the VERHAAK_PN_2017 pathway (Figure 6B,C).[8] Additionally, in patients with GBM, correlation analysis revealed that MSN expression was positively correlated with MES pathway‐related and marker genes (CD44, YKL40, TIMP1, and TGFB1), whereas it was significantly negatively correlated with PN pathway‐related and marker genes (OLIG2, DLL3, SOX2, ASCL1) (Figure 6D).[28, 29, 30] In summary, these results indicate that MSN contributes to the promotion of PMT.