In support, it has been demonstrated that by increasing SIRT1 expression to preserve mitochondrial integrity, the opening of mPTP and doxorubicin‐induced cardiotoxicity can be mitigated.[50, 51] Moreover, mitochondria is necessary for irradiation inducing cellular senescence and cytoplasmic mtDNA triggers cellular senescence and senescence‐associated secretory phenotype (SASP).[52] Our results also suggest that mtDNA‐cGAS‐STING signaling axis leads to expression of pro‐inflammatory cytokines in senescent cardiomyocytes which may explain why DIC are late onset in cancer surviving patients. Here, CGAS is linked to cancer.