Metabolic perturbations, including hyperglycemia, have been shown to affect the rate of DNA demethylation and alter gene transcription activity by regulating the activity of enzymes involved in the balance between DNA methylation and demethylation.[18] We observed that the DSP promoter was hypomethylated under diabetic conditions, and the repression of TET3‐dependent demethylation inhibited the expression of DSP, suggesting a critical role for TET3‐mediated demethylation in regulating DSP expression during wound healing. This evidence concerns the gene TET3 and Hyperglycemia.