According to previous publications, pharmacological inhibition of EZH2 could influence the cell surface expression of MHC‐I (HLA‐A/B/C).[16] However, existing studies have only utilized murine‐derived bladder tumors to investigate the relationship between EZH2 and MHC‐II.[17] To better reflect the relationship between EZH2 and MHC‐I in bladder cancer, we used PDOs co‐culture model to explore the role of EZH2 in bladder cancer. Here, HLA-A is linked to urinary bladder neoplasm.