Among genes crucial for cell cycle regulation,[9] ELF3 had the highest mutation rate (11 out of 15 cases), and a previous paper also reported that ELF3 is one of the most frequently mutated genes in bladder cancer.[10] The co‐deletion of CDKN2A/B occurred in 40% of cases, which is associated with tumor recurrence in certain cancer types.[11] In addition, some commonly mutated genes in bladder cancer, such as RB1, ZFHX3, CCND1, E2F3, and MGA, also exhibited notable mutation frequencies in our sample. Here, CDKN2A is linked to urinary bladder cancer.