E2F3 and cancer: Among genes crucial for cell cycle regulation,[9] ELF3 had the highest mutation rate (11 out of 15 cases), and a previous paper also reported that ELF3 is one of the most frequently mutated genes in bladder cancer.[10] The co‐deletion of CDKN2A/B occurred in 40% of cases, which is associated with tumor recurrence in certain cancer types.[11] In addition, some commonly mutated genes in bladder cancer, such as RB1, ZFHX3, CCND1, E2F3, and MGA, also exhibited notable mutation frequencies in our sample.